Anti-ACVR1, AlpHcAbs® Human antibody

Details and Advantages
Applications: ELISA,Flow Cyt
Reactivity: Human
Conjugate: Unconjugated
Advantages:

High lot-to-lot consistency

Increased sensitivity and higher affinity

Animal-free production

Summary >
Description:
Anti-ACVR1, AlpHcAbs® Human antibody is designed for detecting human ACVR1 specifically. Based on ELISA and/or FCM, Anti-ACVR1, AlpHcAbs® Human antibody reacts with human ACVR1 specifically.

Immunogen: Recombinant human ACVR1
Host: Alpaca pacous
Isotype: Human IgG1
Conjugate: Unconjugated
Specificity: Human ACVR1
Purity: Recombinant Expression and Affinity purified
Concentration: 1mg/ml
Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol
Storage: Store at –20 °C, (Avoid freeze / thaw cycles)

Background:
Activins are a type of dimeric growth and differentiation factor that belong to the transforming growth factor-beta (TGF-beta) superfamily of signaling proteins. They signal through a complex of receptor serine kinases, which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are transmembrane proteins that have a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, while type II receptors are required for binding ligands and for the expression of type I receptors. Upon ligand binding, type I and II receptors form a stable complex, resulting in the phosphorylation of type I receptors by type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.
Performance >
ELISA: 1:4,000-1:10000
Flow Cytometry:1:200-1:1000

Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc. The actual dilution used must be determined empirically.