Among the numerous genes in the genome, 20% to 30% of them encode membrane proteins. Numerous membrane proteins are involved in almost every life activity within cells, including ligand-receptor binding, signal transduction, molecular transport, intercellular recognition and enzyme catalysis, etc., and have extensive application value in biological research and drug development. Therefore, membrane proteins are important targets for numerous drug development and clinical treatment studies. Ion channels, transport proteins, GPCRS and kinases are the largest category of drug targets in drug development. According to statistics, about 50% of drugs target membrane proteins. However, due to the existence of problems such as low expression levels, insolubility in vitro, unstable purification, and difficulty in maintaining natural conformations, the application of transmembrane proteins in drug development is limited. Critical Point Biotech has established a membrane protein antibody research and development platform, which can provide immune methods based on overexpressed cell lines, plasmids, VLPs, micelle, Nanodisc, SMALPS, Salipro, adenovirus, mRNA, etc. At the same time, it combines Apak Biotech's unique water-soluble Adjuvant (Adjuvant Camelid) Code: 600-000-001, which can effectively increase the success rate of immunity.
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Case Study on the Development of Membrane Protein Antibodies
